GLI-1 Polyclonal Antibody, 100ul Peptide Library Increased expression of this gene

Increased expression of this gene leads to translocation of the encoded protein to the cell membrane

This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW)

which belongs to the superfamily of intermediate filament (IF) proteins

but some of the chains have been shown to differ with respect to their tissue distribution

MAP4 and MAPT/TAU

GLI-1 Polyclonal Antibody, 100ul Peptide Library Increased expression of this geneThis gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.