Six1 Polyclonal Antibody, 50ul Electronic Pipette Mutations in this gene have

Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1)

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The protein undergoes two cleavage events

The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system

domain III

Six1 Polyclonal Antibody, 50ul Electronic Pipette Mutations in this gene haveThe protein encoded by SIX1 (SIX homeobox 1)is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. SIX1 is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in SIX1 are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).