Islet-1 Monoclonal Antibody, 100ul[BT-MCA0789] Recombinant Protein Expression ABL1 is a protooncogene that

ABL1 is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes

there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype

22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR

Inhibits the transcriptional activation mediated by PAX5

the interaction prevents processing of p105 to p50

Islet-1 Monoclonal Antibody, 100ul[BT-MCA0789] Recombinant Protein Expression ABL1 is a protooncogene thatThis gene encodes a member of the LIM homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity onset diabetes of the young.