Histone H2B Polyclonal Antibody, 100ul[BT-AP09962] Peripheral Blood Separation Tube Transcripts at this locus may

Transcripts at this locus may also act directly as functional RNAs to recruit transcriptional regulators to the promoter of MYCN and stimulate transcription of this oncogene

and in leukocytes and certain cancer cells

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides

A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration

Alternative splicing results in multiple transcript variants but their biological validity has not been determined

Histone H2B Polyclonal Antibody, 100ul[BT-AP09962] Peripheral Blood Separation Tube Transcripts at this locus mayHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.