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LATS1/2 Polyclonal Antibody, 100ul Low retention tips Noonan syndrome and trisomy 12p

SKU: 49884541440

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LATS1/2 Polyclonal Antibody, 100ul Low retention tips Noonan syndrome and trisomy 12pSerine threonine protein kinase LATS1 2 encoded by LATS1 is a putative serine threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating

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Description

Noonan syndrome and trisomy 12p

suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress

Chromosomal translocation of this gene with the RARA (retinoic acid receptor| alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia

The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells

Mutations in ANKRD26 are associated with autosomal dominant thrombocytopenia-2

LATS1/2 Polyclonal Antibody, 100ul Low retention tips Noonan syndrome and trisomy 12pSerine threonine protein kinase LATS1 2 encoded by LATS1 is a putative serine threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating

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