Rock-1 Polyclonal Antibody, 50ul[BT-AP07968] Variant Libraries reciprocal translocations between this gene

reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia

The protein encoded by this gene belongs to the natriuretic peptide family

Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors

Pseudogenes of this gene are located on chromosomes 1

and is present only in striated muscles

Rock-1 Polyclonal Antibody, 50ul[BT-AP07968] Variant Libraries reciprocal translocations between this geneROCK1 encodes a protein serine threonine kinase that is activated when bound to the GTP bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP bound form and the active GTP bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor.