P53 Polyclonal Antibody, 50ul[BT-AP06811] Gel & Buffers Mice lacking this gene are

Mice lacking this gene are also hypersensitive to interferon| suggesting a function of this protein in downregulating interferon responses| independent of its isopeptidase activity towards ISG15

which is located 10 kb downstream from this gene

In addition| protein levels decrease in the presence of natural killer lytic-associated molecule| suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein

this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity

The encoded protein helps establish epithelial barriers such as those in the organ of Corti

P53 Polyclonal Antibody, 50ul[BT-AP06811] Gel & Buffers Mice lacking this gene areTP53 (tumor protein p53) encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni