Dok-4 Polyclonal Antibody, 100ul Microplate Mixer Mutations in this gene are

Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1

It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane

Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene

involved in retrograde transport of proteins from endosomes to the trans-Golgi network

Its cytosolic localization was demonstrated by cell fractionation experiments

Dok-4 Polyclonal Antibody, 100ul Microplate Mixer Mutations in this gene areThe downstream of kinase family (Dok 1 7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok 4 (Downstream of kinase 4) is a 326 amino acid protein that contains one PH domain and one IRS type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney