FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody, 20ul 3D Culture GPNMB may be involved in

GPNMB may be involved in growth delay and reduction of metastatic potential

The encoded protein plays a role in the inducible expression of cytokine genes in T cells| especially in the induction of interleukin-2 and interleukin-4

a tumor suppressor protein related to APC/beta-catenin signaling pathway

An important paralog of this gene is SLC38A1

which is part of the response to intracellular nitric oxide

FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody, 20ul 3D Culture GPNMB may be involved indisease: A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X; 11)(q13; q23) with MLL HRX. The result is a rogue activator protein. Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin response elements (IREs) and can activate transcription of IGFBP1. Down regulates expression of HIF1A and suppresses hypoxia induced transcriptional activation of HIF1A modulated genes.