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In colon cancer cells (HT-29 and SW480 cells), genetic knockout of IGF-1R or the use of the IGF-1R inhibitor NVP-ADW742 enhanced the killing effect of radiation on cancer cells, confirming that depletion of IGF-1R improves radiosensitivity to colon cancer therapy (145,146)

J Parenter Enteral Nutr

But that study showed that once you start to get to 10 grams, then if you look by MRI, you can start to see that creatine levels are increasing in certain brain regions, perhaps in the brain regions that you were talking about, and theyre going higher than what you would get from just your brain normally making its own creatine

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Impaired mitochondrial fatty acid oxidative flux in fibroblasts from a patient with malonyl-CoA decarboxylase deficiency