Ref-1 (Acetyl Lys6) Polyclonal Antibody, 50ul Cell Screening and Imaging The encoded protein is conserved

The encoded protein is conserved among the mammalian Laurasiatheria branch

also known as the TEA domain (TEAD) family (TEAD1-4)

The protein encoded by this gene belongs to the Fbls class and| in addition to an F-box| contains several tandem leucine-rich repeats

32 and 14 kDa chains

and transduces the signal through a G-protein activated second messenger system

Ref-1 (Acetyl Lys6) Polyclonal Antibody, 50ul Cell Screening and Imaging The encoded protein is conservedApurinic apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. APEX1 encodes the major AP endonuclease in human cells.