A Cyclase V/VI Polyclonal Antibody, 100ul[BT-AP00055] Antibody Humanization PML is often involved in

PML is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL)

The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway

Has DNA-dependent ATPase activity and binds to A/T-rich DNA

and proteolysis

The gene may be regulated by androgens and epigenetic mechanisms

A Cyclase V/VI Polyclonal Antibody, 100ul[BT-AP00055] Antibody Humanization PML is often involved inADCY5 encodes a member (adenylate cyclase 5) of the membrane bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth