4E-BP1 Monoclonal Antibody, 50ul[BT-MCA0091] Bio-Reaction Tube This gene complements an X-linked

This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis

It localizes primarily within subnuclear foci associated with the nuclear matrix

somatic hypermutation and recombination of immunoglobulin genes

The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth

PML is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL)

4E-BP1 Monoclonal Antibody, 50ul[BT-MCA0091] Bio-Reaction Tube This gene complements an X-linkedThis gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV