Mouse Poly Adp Ribose Polymerase 2, PARP2 ELISA Kit, 96T Bottles Stimulates ribosomal RNA synthesis including

Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA

Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B (eukaryotic translation initiation factor 5B)

May have roles in neural function

Defects in EIF2B4 are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy

This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2

Mouse Poly Adp Ribose Polymerase 2, PARP2 ELISA Kit, 96T Bottles Stimulates ribosomal RNA synthesis includingPoly ADP ribosyltransferase that mediates poly ADP ribosylation of proteins and plays a key role in DNA repair (PubMed: 10364231). Mediates glutamate, aspartate or serine ADP ribosylation of proteins: the ADP D ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP ribosyl groups are transferred to the 2' position of the terminal adenosine moiety, building up a polymer with an average chain length of