PDCD5 Polyclonal Antibody, 50ul Purification Members of this family are

Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions

essential for cell survival and development

developmental stage:Expressed in fetal liver (at protein level)

Unlike factor VIII| this gene is transcribed abundantly in a wide variety of cell types

The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction

PDCD5 Polyclonal Antibody, 50ul Purification Members of this family areThis gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12