IRF-3 Polyclonal Antibody, 50ul[BT-AP04629] Immunoassays Proposed to be a ATP-dependent

Proposed to be a ATP-dependent chromatin remodeling protein

and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes

Mutations in this gene have been associated with bone marrow failure syndrome 2

The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases

during the Embden-Meyerhof-Parnas pathway of glycolysis

IRF-3 Polyclonal Antibody, 50ul[BT-AP04629] Immunoassays Proposed to be a ATP-dependentIRF3 encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed