WNK4 Polyclonal Antibody, 50ul Thermal Control Isoform 2 does not interact

Isoform 2 does not interact with CUL4A but still binds to RBX1

Several transcript variants encoding different isoforms have been found for BCKDK

Defects in this gene may be associated with severe combined immunodeficiency (SCID)

Alternate allele-specific splice variants

Involved in innate immnune response

WNK4 Polyclonal Antibody, 50ul Thermal Control Isoform 2 does not interactThis gene encodes a member of the WNK family of serine threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.