DCTN4 Polyclonal Antibody, 100ul Immunoassays DefectsF8 results in hemophilia A

DefectsF8 results in hemophilia A

May exert this function by promoting GLI1 nuclear localization

Some individuals| as represented by the reference genome allele| contain a 2kb coding region deletion and a start code mutation

Nucleosomes wrap and compact DNA into chromatin| limiting DNA accessibility to the cellular machineries which require DNA as a template

PML is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL)

DCTN4 Polyclonal Antibody, 100ul Immunoassays DefectsF8 results in hemophilia ACould have a dual role in dynein targeting and in ACTR1A Arp1 subunit of dynactin pointed end capping. Could be involved in ACTR1A pointed end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.,Belongs to the dynactin subunit 4 family.,subcellular location: Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization