ARAP1 Polyclonal Antibody, 20ul Immune Repertoire Sequencing Mutations in this gene result

Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia

Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum

The protein encoded by this gene belongs to the Fbws class and| in addition to an F-box| contains multiple WD40 repeats

Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells

This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor

ARAP1 Polyclonal Antibody, 20ul Immune Repertoire Sequencing Mutations in this gene resultThe protein encoded by this gene contains SAM, ARF GAP, RHO GAP, ankyrin repeat, RAS associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3) dependent ARF GAP activity. The encoded protein associates with the Golgi, and the ARF GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell specific trafficking of a