RGMC Polyclonal Antibody, 20ul Variant Libraries Pantothenate kinase is a key

Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells

The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha

MIM 151460)

CPN1 encodes the catalytic subunit

which is expressed on neutrophils

RGMC Polyclonal Antibody, 20ul Variant Libraries Pantothenate kinase is a keyThe product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in