Raf-1(Phospho Thr269) Polyclonal Antibody, 20ul Contamination Detection & Removal Represses ligand-dependent transcriptional activation function

Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed: 25661920)

INHBB encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins

Two transcript variants encoding the same protein but differing in the 5' UTR

The product of OTUB1 (OTU deubiquitinase

Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits

Raf-1(Phospho Thr269) Polyclonal Antibody, 20ul Contamination Detection & Removal Represses ligand-dependent transcriptional activation functionThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.