Phospho-BRCA1 (S1423) Polyclonal Antibody, 50ul Reagent Reservoirs The alternative splicing of this

The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation

at least one of which encodes an isoform that is proteolytically processed

Dok-2 and Dok-3 are members of a class of "docking" proteins which contain multiple tyrosine residues and putative SH2 binding sites

|miscellaneous:G0-restricted expression

Alternatively splice transcript variants encoding distinct isoforms have been described

Phospho-BRCA1 (S1423) Polyclonal Antibody, 50ul Reagent Reservoirs The alternative splicing of thisBRCA1 (BRCA1, DNA repair associated) encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi subunit protein complex known as the BRCA1 associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C terminal