Phospho-Amyloid-Beta (T743) Polyclonal Antibody, 100ul Deep Well Plates Alternative splicing of PIK3R1 results

Alternative splicing of PIK3R1 results in four transcript variants encoding different isoforms

May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles

It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets

E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology

This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3)

Phospho-Amyloid-Beta (T743) Polyclonal Antibody, 100ul Deep Well Plates Alternative splicing of PIK3R1 resultsAPP encodes a cell surface receptor and transmembrane precursor protein (amyloid beta precursor protein) that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1 TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are