UNC5D Polyclonal Antibody, 100ul Culture Media Many proteins are tethered to

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor

The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP)| beta (CEBPB) and may play a role in inflammation

Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein

Overexpression of PDK2 may play a role in both cancer and diabetes

An important paralog of this gene is SHF

UNC5D Polyclonal Antibody, 100ul Culture Media Many proteins are tethered toReceptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.,PTM: Phosphorylated on cytoplasmic tyrosine residues.,PTM: