MMP-12 Polyclonal Antibody, 100ul[BT-AP05476] Inoculating Loops/Needles The caudal type homeobox 2

The caudal type homeobox 2 is a major regulator of intestine-specific genes involved in cell growth an differentiation

Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed: 18235501

The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha

Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy

Expression of this gene is retina-specific

MMP-12 Polyclonal Antibody, 100ul[BT-AP05476] Inoculating Loops/Needles The caudal type homeobox 2Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, Stromelysin 3 encoded by MMP11 is activated