PPR1A Polyclonal Antibody, 50ul Supplements The encoded protein undergoes an

The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the Catalytic activity is acquired

The isoform type 3 can inhibit the function of isoforms type

but causes G2-M arrest in p53-null or –mutant cells

This gene is part of the family of Rho guanine nucleotide exchange factors

Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure

PPR1A Polyclonal Antibody, 50ul Supplements The encoded protein undergoes anInhibitor of protein phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I 1 activity in many tissues. I 1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I 1 is inactivated by calcineurin (or PP2B). Does not inhibit type 2 phosphatases.,PTM: Phosphorylation of Thr 35 is