Insulin Polyclonal Antibody, 100ul[BT-AP10405] Stepper Mutations in this gene are

Mutations in this gene are associated with the French-Canadian type of Leigh syndrome

enzyme regulation:Activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39

|Belongs to the protein kinase superfamily

The encoded protein also plays a role in the repression of inflammatory genes as a component of the IFN-gamma-activated inhibitor of translation (GAIT) complex

lipid metabolism

Insulin Polyclonal Antibody, 100ul[BT-AP10405] Stepper Mutations in this gene areAfter removal of the precursor signal peptide, proinsulin is post translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read through gene, INS IGF2, which overlaps with this gene at