APEX2 Rabbit Polyclonal Antibody, 100ul Molecular Biology The encoded protein binds to

The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis

a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation

Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed: 18235501

olfactory bulb

as well as in non-gustatory cells including those of the brain

APEX2 Rabbit Polyclonal Antibody, 100ul Molecular Biology The encoded protein binds toApurinic apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II