Collagen XVIII alpha 1(Cleaved-His1572) Rabbit Polyclonal Antibody, 100ul Site-directed Mutagenesis Two alternatively spliced transcript variants

Two alternatively spliced transcript variants have been found for this gene

promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins

an arrangement which is thought to have evolved by a series of gene duplications

The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region

A mutation in this gene was found in individuals with dementia with Lewy bodies

Collagen XVIII alpha 1(Cleaved-His1572) Rabbit Polyclonal Antibody, 100ul Site-directed Mutagenesis Two alternatively spliced transcript variantsThis gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins extracellular matrix proteins that contain multiple triple helix domains (collagenous domains) interrupted by non collagenous domains. A long isoform of the protein has an N terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C terminal domain results in