MEK Kinase-1 Polyclonal Antibody, 20ul[BT-AP05333] Site-directed Mutagenesis resulting in the inhibition of

resulting in the inhibition of TRAF6 NF-kappa-B activation

Component of the little elongation complex (LEC)

and in the 3' UTR of transferrin receptor mRNA

Alternate splicing results in multiple transcript variants

Heterozygous mutations in the this gene cause auditory-pigmentary syndromes

MEK Kinase-1 Polyclonal Antibody, 20ul[BT-AP05333] Site-directed Mutagenesis resulting in the inhibition ofThe protein encoded by MAP3K1 (mitogen activated protein kinase kinase kinase 1) is a serine threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF kappa B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N