SACS Polyclonal Antibody, 100ul Lentiviral Packaging Multiple alternatively spliced variants encoding

Multiple alternatively spliced variants encoding different isoforms have been identified

May form a cell surface vasopressin receptor

and his-asp-glu-leu (HDEL) in S

Binding occurs as a ternary complex of methionyl-tRNA

They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates

SACS Polyclonal Antibody, 100ul Lentiviral Packaging Multiple alternatively spliced variants encodingThis gene encodes the sacsin protein, which includes a UbL domain at the N terminus, a DnaJ domain, and a HEPN domain at the C terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12. 8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix Saguenay (ARSACS), a neurodegenerative