Rb (Acetyl-K873/K874) Polyclonal Antibody, 20ul Vortex Mixer Several transcript variants encoding different

Several transcript variants encoding different isoforms have been found for this gene

Mutations in this gene are a cause of spastic ataxia 2| autosomal recessive

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues

also named as CK1

members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain

Rb (Acetyl-K873/K874) Polyclonal Antibody, 20ul Vortex Mixer Several transcript variants encoding differentThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.