Apaf-1 Polyclonal Antibody, 20ul Buffer Solutions ®VitroGel Hydrogel Matrix is an

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Apaf-1 Polyclonal Antibody, 20ul Buffer Solutions ®VitroGel Hydrogel Matrix is anAPAF1 encodes a cytoplasmic protein that initiates apoptosis. Apoptotic protease activating factor 1 contains several copies of the WD 40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade