ASCL1 Polyclonal Antibody, 50ul[BT-AP00664] Bottle-Top Dispenser termed the anaphase-promoting complex (APC)

termed the anaphase-promoting complex (APC)

This complex is required for the conversion of interphase chromatin into condensed chromosomes

Contains 1 CS domain

suggesting the presence of a cancer susceptibility locus

there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype

ASCL1 Polyclonal Antibody, 50ul[BT-AP00664] Bottle-Top Dispenser termed the anaphase-promoting complex (APC)ASCL1 encodes a member of the basic helix loop helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5' CANNTG 3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central