p56Dok-2(Phospho-Tyr351) Rabbit Polyclonal Antibody, 20ul Cell Culture Mutations in ZNF592 have been

Mutations in ZNF592 have been associated with autosomal recessive spinocerebellar ataxia

This gene encodes a member of a family of neuronal cell surface proteins

and an ATPase domain (NB-ARC)

Undetectable in other tissues

A second transferrin receptor

p56Dok-2(Phospho-Tyr351) Rabbit Polyclonal Antibody, 20ul Cell Culture Mutations in ZNF592 have beenThe protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr abl) a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.