Raf-1(Phospho Ser621) Polyclonal Antibody, 50ul ssDNA Synthesis The tyrosine-phosphorylated protein binds the

The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11

which contains a mitochondrial targeting signal that is essential for mitochondrial localization

Cleavage of the precursor generates alpha and beta subunits

MAPKAPK2 (mitogen-activated protein kinase-activated protein kinase 2) encodes a member of the Ser/Thr protein kinase family

which suggests its role in PI(3) kinase-mediated signaling events

Raf-1(Phospho Ser621) Polyclonal Antibody, 50ul ssDNA Synthesis The tyrosine-phosphorylated protein binds theThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.