CD27 Polyclonal Antibody, 100ul Antibodies The C region genes are

The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14

This PTP contains a C-terminal PEST motif

The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal| followed by two fibronectin type-III motifs

The majority of autoantibodies to p70 in most sera from patients with SLE seem to be reactive with this region

|PTM:Phosphorylated when associated with the catalytic subunit

CD27 Polyclonal Antibody, 100ul Antibodies The C region genes areThe protein encoded by this gene is a member of the TNF receptor superfamily. This receptor is required for generation and long term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF kappaB and MAPK8 JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this