PSP Polyclonal Antibody, 100ul Immuno Plates Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression

Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression

The encoded protein| upon tyrosine phosphorylation| has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2

Two transcript variants encoding the same protein have been identified

This protein also promotes the nuclear translocation of p120

and functions in adhesion and activation of T lymphocytes

PSP Polyclonal Antibody, 100ul Immuno Plates Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repressionPSPN encodes a secreted ligand of the GDNF (glial cell line derived neurotrophic factor) subfamily and TGF beta (transforming growth factor beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. Persephin signals through the RET receptor tyrosine kinase and a GPI linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system