DNJC3 Polyclonal Antibody, 20ul Centrifuges Studies of the rat homolog

Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection

The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity

Related pseudogenes exist on chromosomes 2 and X

Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product

The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins

DNJC3 Polyclonal Antibody, 20ul Centrifuges Studies of the rat homologThis gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon induced, dsRNA activated protein kinase (PKR).