FoxO3A (Acetyl Lys569) Rabbit Polyclonal Antibody, 20ul Cellular Function Assays Transmembrane topology has been established

Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2)| with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane

The protein localizes to the nucleoplasm and nucleoli

This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18

as well as for its stimulation of basic fibroblast growth factor expression

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FoxO3A (Acetyl Lys569) Rabbit Polyclonal Antibody, 20ul Cellular Function Assays Transmembrane topology has been establisheddisease: A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6; 11)(q21; q23) with MLL HRX. Transcriptional activator which triggers apoptosis in the absence of survival factors including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'