Rb(Phospho Ser608) Polyclonal Antibody, 50ul Biomatrix The SPTLC3 gene encodes an

The SPTLC3 gene encodes an isoform of the third subunit of serine palmitoyltransferase (SPT

regulates the properties of that enzyme

Beta defensin genes are found in several clusters throughout the genome| with this gene mapping to a cluster at 20p13

Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma

This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias

Rb(Phospho Ser608) Polyclonal Antibody, 50ul Biomatrix The SPTLC3 gene encodes anThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.