LRIG1 Polyclonal Antibody, 20ul Variant Libraries The protein also functions as

The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase

This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10

Alternative splicing seems to be a common mechanism in this gene family

The mammalian protein is involved in tumor suppression pathways

is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils

LRIG1 Polyclonal Antibody, 20ul Variant Libraries The protein also functions asThe LRRs and the Ig domains are each sufficient for EGFR ERBB1 binding. This interaction is abolished only when these two domains are deleted.,Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.,induction: By EGF.,Contains 17 LRR (leucine rich) repeats.,Contains 3 Ig like C2 type (immunoglobulin like)