Raf-1(Phospho Ser642) Polyclonal Antibody, 100ul Lysosome with variations due to deletions

with variations due to deletions

The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride

and siRNA maturation

induction:By TNF-alpha and interleukin-1 beta

This protein has also been reported to have a role in cancer metastasis

Raf-1(Phospho Ser642) Polyclonal Antibody, 100ul Lysosome with variations due to deletionsThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.