INVS Polyclonal Antibody, 20ul Pasteur Pipets The protein encoded by FKBPL

The protein encoded by FKBPL (FK506 binding protein like) has similarity to the immunophilin protein family

This subunit is present in 4-5 copies per dynactin molecule

Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation

2006 [PubMed: 16426570])

suggesting that either it is functionally inactive or that it may have acquired a pancreatic polypeptide-independent function

INVS Polyclonal Antibody, 20ul Pasteur Pipets The protein encoded by FKBPLThis gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin binding domains. The encoded protein may function in renal tubular development and function, and in left right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with