PLEK2 Rabbit Polyclonal Antibody, 100ul Roller Bottles Multiple transcript variants due to

Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene

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Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones

Mutations in PRKAR1A cause Carney complex (CNC)

Mutations in this gene cause Schwartz-Jampel syndrome type 2

PLEK2 Rabbit Polyclonal Antibody, 100ul Roller Bottles Multiple transcript variants due toThe protein encoded by this gene associates with membrane bound phosphatidylinositols generated by phosphatidylinositol 3 kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1 q subcomponent B chain (C1QB) this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease.