DAB2 Rabbit Polyclonal Antibody, 100ul Protein Post-translational Modification epidermal keratinocytes

epidermal keratinocytes

It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs)

They are differentially regulated after early development

and being expressed in vascular endothelium cells and binding to L-selectin

Gene Ontology (GO) annotations related to RABEP2 include GTPase activator activity and growth factor activity

DAB2 Rabbit Polyclonal Antibody, 100ul Protein Post-translational Modification epidermal keratinocytesThis gene encodes a mitogen responsive phosphoprotein. It is expressed in normal ovarian epithelial cells but is down regulated or absent from ovarian carcinoma cell lines suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2 an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras) via its C terminal proline rich sequences and may thus modulate growth factor Ras