CD58 Polyclonal Antibody, 50ul[BT-AP01601] Micro Centrifuge Tubes Some haplotypes of this gene

Some haplotypes of this gene show a positive association with schizophrenia

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer

and at slightly lower levels in fetal brain

This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis

A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors

CD58 Polyclonal Antibody, 50ul[BT-AP01601] Micro Centrifuge Tubes Some haplotypes of this geneCell division cycle 6encoded by CDC6 is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks.