PTEN(Phospho Ser370) Polyclonal Antibody, 100ul Serological Pipets This gene is disrupted in

This gene is disrupted in a t(1

It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs

The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex

The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1

CCNC and CDK8 subunits form a distinct module termed the CDK8 module

PTEN(Phospho Ser370) Polyclonal Antibody, 100ul Serological Pipets This gene is disrupted inThis gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide