APBB3 Rabbit Polyclonal Antibody, 50ul Syringe Filter Mutations in this gene have

Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy

The expression of AIFM2 is also found to be induced by tumor suppressor protein p53 in colon cancer cells

and endocytic recycling of LDL receptors

The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells

This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression

APBB3 Rabbit Polyclonal Antibody, 50ul Syringe Filter Mutations in this gene haveThe protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta amyloid precursor protein (APP) as well as to other APP like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene.