ULK3 Polyclonal Antibody, 100ul Thermal Control It is an essential component

It is an essential component of the transcription factor TFIIH

Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN7)

FZD7 expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas

which form a tetrameric holoenzyme

A read-through INS-IGF2 gene exists| whose 5' region overlaps the INS gene and the 3' region overlaps this gene

ULK3 Polyclonal Antibody, 100ul Thermal Control It is an essential componentSerine threonine protein kinase which enhances GLI1 and GLI2 transcriptional activity and consequently positively regulates GLI dependent SHH signaling. May exert this function by promoting GLI1 nuclear localization. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently.